IKZF3 Rabbit Monoclonal Antibody (CAB8614)
- SKU:
- CAB8614
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- AIO
- AIOLOS
- ZNFN1A3
- Research Area:
- Immunology
Description
Product Name: | IKZF3 Rabbit Monoclonal Antibody |
SKU: | CAB8614 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 400-509 of human IKZF3 (Q9UKT9). |
Sequence: | IYQQ NHMV LSRA RNGM PLLK EVPR SYEL LKPP PICP RDSV KVIN KEGE VMDV YRCD HCRV LFLD YVMF TIHM GCHG FRDP FECN MCGY RSHD RYEF SSHI ARGE HRAL LK |
Tested Applications: | WB IHC-P IF/ICC IP ELISA |
Recommended Dilution: | WB,1:100 - 1:500 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells |
Synonyms: | AIO; IMD84; AIOLOS; ZNFN1A3; IKZF3 |
Positive Sample: | Raji,Mouse spleen,Mouse thymus,Rat lung |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Cytosol, Nucleoplasm, Nucleus |
Calculated MW: | 58kDa |
Observed MW: | 65kDa |
This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants.
Purification Method: | Affinity purification |
Gene ID: | 22806 |
Clone Number: | ARC2781 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |