The IKBα Polyclonal Antibody (CAB11168) is specifically designed for research involving IKBα, a key regulatory protein involved in inflammatory signaling pathways. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in applications such as Western blotting. By binding to the IKBα protein, this antibody allows for the detection and analysis of IKBα levels in various cell types, making it an ideal tool for studying the role of IKBα in immune regulation and inflammatory responses.IKBα plays a crucial role in the modulation of NF-κB signaling, a pathway involved in the regulation of immune and inflammatory responses.
Dysregulation of NF-κB signaling, often associated with abnormal IKBα function, has been implicated in various diseases including autoimmune disorders, inflammatory conditions, and cancer. Therefore, understanding the function of IKBα and its role in NF-κB signaling is essential for developing targeted therapies for these diseases.Overall, the IKBα Polyclonal Antibody (CAB11168) is a valuable tool for researchers studying the molecular mechanisms underlying inflammatory responses and immune regulation. Its high specificity and sensitivity make it a reliable choice for investigating the role of IKBα in health and disease.
Product Name:
[KO Validated] IκBα Rabbit Polyclonal Antibody
SKU:
CAB11168
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-317 of human IκBα (NP_065390.1).
This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease.
Purification Method:
Affinity purification
Gene ID:
4792
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using IκBα antibody (CAB11168) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
