null

Anti-IGLL1 Antibody (CAB20257)

SKU:
CAB20257
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
IGO
14.1
AGM2
IGL1
IGL5
IGLL
IGVPB
CD179b
VPREB2
IGLJ14.1
$431
Frequently bought together:

Description

Product Name:IGLL1 Rabbit pAb
Product Code:CAB20257
Size:50uL, 100uL
Synonyms:IGO, 14.1, AGM2, IGL1, IGL5, IGLL, IGVPB, CD179b, VPREB2, IGLJ14.1
Applications:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant protein of human IGLL1.
Applications:WB
Recommended Dilutions:WB 1:1000 - 1:2000
Reactivity:Human
Immunogen:Recombinant protein of human IGLL1.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:3543
Uniprot:P15814
Calculated MW:23kDa
Observed MW:Refer to figures
UniProt Protein Function:IGLL1: Critical for B-cell development. Defects in IGLL1 are the cause of agammaglobulinemia type 2 (AGM2). It is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 22q11.23 Cellular Component: external side of plasma membrane; membrane Molecular Function: antigen binding Biological Process: B cell receptor signaling pathway; complement activation, classical pathway; defense response to bacterium; immune response; innate immune response; phagocytosis, engulfment; phagocytosis, recognition; positive regulation of B cell activation Disease: Agammaglobulinemia 2, Autosomal Recessive
UniProt Protein Details:
NCBI Summary:The preB cell receptor is found on the surface of proB and preB cells, where it is involved in transduction of signals for cellular proliferation, differentiation from the proB cell to the preB cell stage, allelic exclusion at the Ig heavy chain gene locus, and promotion of Ig light chain gene rearrangements. The preB cell receptor is composed of a membrane-bound Ig mu heavy chain in association with a heterodimeric surrogate light chain. This gene encodes one of the surrogate light chain subunits and is a member of the immunoglobulin gene superfamily. This gene does not undergo rearrangement. Mutations in this gene can result in B cell deficiency and agammaglobulinemia, an autosomal recessive disease in which few or no gamma globulins or antibodies are made. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:P15814
NCBI GenInfo Identifier:123944
NCBI Gene ID:3543
NCBI Accession:P15814.1
UniProt Secondary Accession:P15814,Q0P681
UniProt Related Accession:P15814
Molecular Weight:8,574 Da
NCBI Full Name:Immunoglobulin lambda-like polypeptide 1
NCBI Synonym Full Names:immunoglobulin lambda like polypeptide 1
NCBI Official Symbol:IGLL1  
NCBI Official Synonym Symbols:IGO; 14.1; AGM2; IGL1; IGL5; IGLL; IGVPB; CD179b; VPREB2; IGLJ14.1  
NCBI Protein Information:immunoglobulin lambda-like polypeptide 1
UniProt Protein Name:Immunoglobulin lambda-like polypeptide 1
UniProt Synonym Protein Names:CD179 antigen-like family member B; Ig lambda-5; Immunoglobulin omega polypeptide; Immunoglobulin-related protein 14.1; CD_antigen: CD179b
Protein Family:Ig lambda chain C region
UniProt Gene Name:IGLL1  
UniProt Entry Name:IGLL1_HUMAN

Related Products