The Anti-IGF1R Chimeric Recombinant Rabbit Monoclonal Antibody (HDAB0332) is a cutting-edge tool for researchers studying the IGF1R (Insulin-like Growth Factor 1 Receptor) protein, a key player in cell growth, differentiation, and survival. This antibody, developed using rabbit monoclonal technology, boasts high specificity and sensitivity for detecting IGF1R in various samples, particularly human tissues.IGF1R is a critical receptor involved in various physiological processes, including regulating cell proliferation and metabolism. Dysregulation of IGF1R signaling has been linked to cancer development and progression, making it an attractive target for cancer research and therapeutic interventions.
The Anti-IGF1R Antibody offers researchers a reliable means to study IGF1R expression and activation levels in cancer cells, aiding in the development of targeted therapies for cancer treatment.With its superior performance in applications such as Western blotting, immunohistochemistry, and flow cytometry, the Anti-IGF1R Chimeric Recombinant Rabbit Monoclonal Antibody is a valuable tool for advancing research in oncology and molecular biology. Its versatility and precision make it an essential component for investigating the role of IGF1R in cancer biology and exploring new avenues for therapeutic interventions.
SKU:
HDAB0332
Size:
100 µg
Clonality:
Monoclonal
Clone:
DMC684
Synonyms:
CD221; IGFIR; IGFR; JTK13
Applications:
Flow Cyt
Recommended Dilution:
Flow Cyt 1:100
Host Species:
Rabbit
Isotype:
Rabbit/Human Fc chimeric IgG1
Reactivity:
Human
Purification Method:
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]
