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VivoGenie Anti-Human PD-1 (Genolimzumab) Biosimilar (IVMB0536)

SKU:
IVMB0536
Antibody Type:
In Vivo Biosimilar
Endotoxin Level:
Low Endotoxin
Applications:
In Vivo
Disease Area:
Cancer Immunotherapy
Disease Area:
Autoimmune Diseases
€429 - €14,099

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Anti-Human PD-1 (Genolimzumab)
SKU:IVMB0536
Size:1 mg, 5 mg, 25 mg, 50 mg, 100 mg
Antibody Type:Biosimilar Recombinant Human Monoclonal Antibody
Clone:GB226
Target:PD-1
Isotype:Human IgG4κ
Host Species:Human
Reactivity:Human
Applications:ELISA
Expression Host:HEK-293 Cells
FC Effector Activity:Active
Synonyms:CD279, PD1, Anti-PD1, PDCD1
Product Concentration:≥ 5.0 mg/ml
Purity:≥95% by SDS Page
Immunogen:Human PD-1
Endotoxin Level:< 1.0 EU/mg as determined by the LAL method
Antigen Distribution:PD-1 is expressed on activated T cells, B cells, a subset of thymocytes, macrophages, dendritic cells, and some tumor cells and is also retained in the intracellular compartments of regulatory T cells (Tregs).
Formulation:This biosimilar antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Specificity:Genolimzumab activity is directed against human and cynomolgus PD-1.
Additional Applications Reported In Literature:ELISAWBIPFAFCB
Recommended Isotype Controls:Human IgG4

PD-1 is a transmembrane protein in the CD28/CTLA-4 subfamily of the Ig superfamily 1,2. When stimulated via the T cell receptor (TCR), Tregs translocate PD-1 to the cell surface 3. Programmed cell death 1 ligand 1 (PD-L1; CD274; B7H1) and programmed cell death 1 ligand 2 (PD-L2; CD273; B7DC) have been identified as PD-1 ligands 1. PD-1 is co-expressed with PD-L1 on tumor cells and tumor-infiltrating antigen-presenting cells (APCs) 2. Additionally, PD-1 is co-expressed with IL2RA on activated CD4+ T cells 3.

PD-1 is an immune checkpoint receptor that suppresses cancer-specific immune responses 4. Additionally, PD-1 acts as a T cell inhibitory receptor and plays a critical role in peripheral tolerance induction and autoimmune disease prevention as well as important roles in the survival of dendritic cells, macrophage phagocytosis, and tumor cell glycolysis 2. PD-1 prevents uncontrolled T cell activity, leading to attenuation of T cell proliferation, cytokine production, and cytolytic activities. Additionally, the PD-1 pathway is a major mechanism of tumor immune evasion, and, as such, PD-1 is a target of cancer immunotherapy 2.

Genolimzumab is a humanized IgG4 monoclonal antibody that targets PD-1 and prevents binding to PD-L1 and PD-L2 ligands, allowing T cell activation and tumor cell death 5,6. Genolimzumab has very low antibody-dependent cell mediated cytotoxicity and complement-dependent cytotoxicity 5. Genolimzumab does not completely block nivolumab or pembrolizumab binding to PD-1, suggesting the use of a novel binding epitope 6. Anti-tumor activity has been demonstrated in various clinical trials5.

Ligand/Receptor:PD-L1, CD274
State of Matter:Liquid
Regulatory Status:Research Use Only (RUO). Non-Therapeutic.
Product Preparation:Recombinant biosimilar antibodies are manufactured in an animal free facility using onlyin vitroprotein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Storage and Handling:Functional grade biosimilar antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
UniProt:Q9UMF3
Research Area:Biosimilars

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