Anti-Human IL-6 (Sarilumab) - Fc Reduced HRP Biosimilar (IVMB0462)
- SKU:
- IVMB0462
- Antibody Type:
- HRP Biosimilar
- Modifications:
- HRP-Conjugated
- Applications:
- IHC
- ELISA
- Drug Development
- Inflammation Assays
- Inflammatory Response Assays
- Pharmacokinetics
- Disease Area:
- Inflammatory Diseases
- Disease Area:
- Autoimmune Disorders
Description
| Product Name: | Anti-Human IL-6 (Sarilumab) - HRP |
| SKU: | IVMB0462 |
| Size: | 100 µg |
| Antibody Type: | Biosimilar Recombinant Human Monoclonal Antibody |
| Clone: | Hu137 |
| Target: | IL-6 |
| Isotype: | Human IgG1κ |
| Host Species: | Human |
| Reactivity: | Human |
| Applications: | ELISA |
| Expression Host: | HEK-293 Cells |
| FC Effector Activity: | Muted |
| Synonyms: | Interleukin-6, CDF; HGF; HSF; BSF2; BSF-2; IFNB2; IFN-beta-2 |
| Product Concentration: | 0.5 mg/ml |
| Applications and Recommended Usage: | FC The suggested concentration for Alemtuzumab biosimilar antibody for staining cells in flow cytometry is ≤ 1.0 μg per 106 cells in a volume of 100 μl. Titration of the reagent is recommended for optimal performance for each application. ELISA |
| Antigen Distribution: | IL-6R is ubiquitously expressed. |
| Formulation: | This HRP-conjugated antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4, 1% BSA. (Warning: Use of sodium azide as a preservative will inhibit the enzyme activity of horseradish peroxidase) |
| Specificity: | This non-therapeutic antibody uses the same variable region sequence as the therapeutic antibody Sarilumab. Sarilumab binds to the transmembrane and soluble forms of the IL-6 receptor. This product is for research use only. |
| Additional Applications Reported In Literature: | FA |
| Additional Reported Applications For Relevant Conjugates: | BNIHC (Paraffin)IHC (Frozen)WB |
IL-6 and its signaling pathway play a part in immune response regulation, inflammation, and hematopoiesis.2 Sarilumab is a research-grade recombinant human monoclonal IL-6 receptor antagonist. It specifically binds to both the transmembrane and soluble forms of the IL-6 receptor, thus inhibiting IL-6–mediated cis and trans-signaling in a dose-dependent manner.1 Therapeutic Sarilumab, also known by the trade name Kevzara, is currently used to treat Rheumatoid Arthritis1, however, as of March 2020, The Feinstein Institute of Northwell Health publicized a study on "a human antibody that may prevent the activity" of IL-6 for the treatment of COVID-19.3 Anti-Human IL-6 (Sarilumab) utilizes the same variable regions from the therapeutic antibody Sarilumab making it ideal for research projects.
| Regulatory Status: | Research Use Only (RUO). Non-Therapeutic. |
| Storage and Handling: | This horseradish peroxidase conjugated monoclonal antibody is stable when stored at 2-8°C.Do not freeze. |
| Research Area: | Biosimilars |
Related Products
Anti-Human IL-6 (Sarilumab) - HRP Biosimilar (IVMB0458)
Anti-Human IL-6 (Sarilumab) - Fc Reduced Biotin Biosimilar (IVMB0461)
VivoGenie Anti-IL-6 (Sarilumab) Biosimilar (Fc Reduced) (IVMB0220)
Anti-Human IL-6 (Sarilumab) - APC Biosimilar (IVMB0459)
