The Anti-Human IgA Antibody (CAB19704) is a powerful tool for researchers studying the IgA antibody, an important player in the body's immune response. This antibody, produced in rabbits, has high reactivity with human samples and is validated for use in various applications, including Western blotting. By binding specifically to the IgA antibody, this antibody allows for accurate detection and analysis in a variety of cell types, making it a valuable resource for studies in immunology, infectious diseases, and autoimmune disorders.IgA is the most abundant antibody in mucosal secretions and plays a crucial role in defending against pathogens at mucosal surfaces.
Dysregulation of IgA production has been implicated in various diseases, including allergies, autoimmune disorders, and infections. By targeting the IgA antibody, researchers can gain insights into the immune response mechanisms underlying these conditions and potentially develop new strategies for treatment and prevention.In summary, the Anti-Human IgA Antibody (CAB19704) offers a precise and reliable tool for studying the IgA antibody and its role in immune function and disease. Its high specificity and sensitivity make it a valuable asset for research in a wide range of scientific disciplines.
Product Name:
Human IgA Rabbit Monoclonal Antibody
SKU:
CAB19704
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-353 of human IgA (P01876).
blood microparticle, external side of plasma membrane, extracellular exosome, extracellular region, extracellular space, immunoglobulin complex, circulating
Calculated MW:
60kDa
Observed MW:
55kDa
Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens. The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen. Ig alpha is the major immunoglobulin class in body secretions.
Purification Method:
Affinity purification
Gene ID:
3493/3494
Clone Number:
ARC2239
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of Human plasma, using Human IgA antibody (CAB19704) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
