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Anti-Human ICAM-1 In Vivo Antibody - Ultra Low Endotoxin

SKU:
IVMB0135
Product Type:
In Vivo Monoclonal Antibody
Clone:
15.2
Protein:
ICAM-1
Isotype:
Mouse IgG1
Reactivity:
Human
Synonyms:
BB2
CD54
P3.58
Endotoxin Level:
Ultra Low Endotoxin
Host Species:
Mouse
Applications:
FC
IHC FFPE
IP
WB
$322 - $4,704
Frequently bought together:

Description

system_update_altTechnical Datasheet
Product Name:Anti-Human ICAM-1 In Vivo Antibody - Ultra Low Endotoxin
Product Code:IVMB0135
Size:1mg, 5mg, 25mg, 50mg, 100mg
Clone:15.2
Protein:ICAM-1
Product Type:Monoclonal Antibody
Synonyms:BB2, CD54, P3.58
Isotype:Mouse IgG1
Reactivity:Human
Immunogen:Human infant thymocytes and Sezary cells
Applications:FC, IHC FFPE, IP, WB
Formulation:This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added.
Endotoxin Level:<0.5 EU/mg as determined by the LAL method
Purity:≥98% monomer by analytical SEC
>95% by SDS Page
Preparation:Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Storage and Handling:Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
Product CodeProduct NameEndotoxin Level
IVMB0134Anti-Human ICAM-1 In Vivo Antibody - Low EndotoxinLow
IVMB0135Anti-Human ICAM-1 In Vivo Antibody - Ultra Low EndotoxinUltra Low
Applications:FC, IHC FFPE, IP, WB
Recommended Usage:FC
WB
Reactivity:Human
Host Species:Mouse
Specificity:Mouse Anti-Human Inter-Cellular Adhesion Molecule 1 (Clone 15.2) recognizes an epitope on Human ICAM-1. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Antigen Distribution:CD54 is present on endothelial cells, lymphocytes, epithelial cells, dendritic cells and keratinocytes.
Immunogen:Human infant thymocytes and Sezary cells
Concentration:≥ 5.0 mg/ml
Endotoxin Level:<0.5 EU/mg as determined by the LAL method
Purity:≥98% monomer by analytical SEC
>95% by SDS Page
Formulation:This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added.
Preparation:Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Storage and Handling:Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.

ICAM-1 is a 55 kDa glycoprotein that is part of the Ig superfamily. It is heavily glycosylated to form 75 kDa to 115 kDa. ICAM-1 is known to be an adhesion and viral entry molecule, and its long suspected involevement in signal transduction is being elucidated. The signal-transducing functions of ICAM-1 appear to be mainly associated with proinflammatory pathways. Furthermore, ICAM-1 signaling appears to act as a beacon for inflammatory immune cells such as macrophages and granulocytes bringing about inflammation via lymphocyte trafficking. ICAM-1 is essential for the transmigration of leukocytes out of blood vessels and into tissues, and is a marker of endothelial dysfunction leading to damaging vascular disorders in umbilical and placental vascular tissue of gestational pregnancies. ICAM-1 is the receptor for rhinoviruses (the cause of most common colds) and malaria, and plays an inflammatory role in ocular allergies.

Technical Datasheet:View
Protein:ICAM-1
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Mouse IgG1 Isotype Control [HKSP84]
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Isotype Mouse IgG1
Endotoxin Level Ultra Low Endotoxin
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Product Thumbnail
Mouse IgG1 Isotype Control [HKSP]
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Isotype Mouse IgG1
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Shane Costigan

Shane Costigan

Territory Manager & Team Lead

Abdul Khadim

Abdul Khadim

Sales Executive

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