null

Anti-Human ICAM-1 In Vivo Antibody - Low Endotoxin

SKU:
IVMB0134
Product Type:
In Vivo Monoclonal Antibody
Clone:
15.2
Protein:
Inter-Cellular Adhesion Molecule 1
Isotype:
Mouse IgG1
Reactivity:
Human
Synonyms:
BB2
CD54
P3.58
Endotoxin Level:
Low Endotoxin
Host Species:
Mouse
Applications:
FC
IHC FFPE
IP
WB
€125 - €3,220
Frequently bought together:

Description

system_update_altTechnical Datasheet

Anti-Human ICAM-1 In Vivo Antibody - Low Endotoxin

Introducing the Anti-Human ICAM-1 In Vivo Antibody - Low Endotoxin from Assay Genie, a highly specific monoclonal antibody designed for in vivo applications.

This antibody targets the Intercellular Adhesion Molecule 1 (ICAM-1), a critical protein involved in the inflammatory response and immune cell adhesion, making it an excellent tool for research in immunology, inflammation, and related fields. With a mouse IgG1 isotype, it ensures high purity and low endotoxin levels (<0.1 EU/μg), ensuring optimal performance in ELISA, flow cytometry, immunohistochemistry, and other assays. Available in various sizes, it is formulated in phosphate-buffered saline for stability and efficacy. Enhance your research with this reliable and versatile antibody. ICAM-1 is a glycoprotein expressed on the surface of endothelial cells, immune cells, and some epithelial cells. It plays a significant role in the immune system by facilitating leukocyte endothelial transmigration, a key process in the inflammatory response, through interaction with integrins on leukocytes.

Product Name:Anti-Human ICAM-1 In Vivo Antibody - Low Endotoxin
Product Code:IVMB0134
Size:1mg, 5mg, 25mg, 50mg, 100mg
Clone:15.2
Protein:Inter-Cellular Adhesion Molecule 1
Product Type:Monoclonal Antibody
Synonyms:BB2, CD54, P3.58
Isotype:Mouse IgG1
Reactivity:Human
Immunogen:Human infant thymocytes and Sezary cells
Applications:FC, IHC FFPE, IP, WB
Formulation:This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added.
Endotoxin Level:< 1.0 EU/mg as determined by the LAL method
Purity:≥95% monomer by analytical SEC
>95% by SDS Page
Preparation:Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Storage and Handling:Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
Product CodeProduct NameEndotoxin Level
IVMB0134Anti-Human ICAM-1 In Vivo Antibody - Low EndotoxinLow
IVMB0135Anti-Human ICAM-1 In Vivo Antibody - Ultra Low EndotoxinUltra Low
Applications:FC, IHC FFPE, IP, WB
Reactivity:Human
Host Species:Mouse
Specificity:Mouse Anti-Human Inter-Cellular Adhesion Molecule 1 (Clone 15.2) recognizes an epitope on Human ICAM-1. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Antigen Distribution:CD54 is present on endothelial cells, lymphocytes, epithelial cells, dendritic cells and keratinocytes.
Immunogen:Human infant thymocytes and Sezary cells
Concentration:≥ 5.0 mg/ml
Endotoxin Level:< 1.0 EU/mg as determined by the LAL method
Purity:≥95% monomer by analytical SEC
>95% by SDS Page
Formulation:This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added.
Preparation:Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Storage and Handling:Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.

ICAM-1 is a 55 kDa glycoprotein that is part of the Ig superfamily. It is heavily glycosylated to form 75 kDa to 115 kDa. ICAM-1 is known to be an adhesion and viral entry molecule, and its long suspected involevement in signal transduction is being elucidated. The signal-transducing functions of ICAM-1 appear to be mainly associated with proinflammatory pathways. Furthermore, ICAM-1 signaling appears to act as a beacon for inflammatory immune cells such as macrophages and granulocytes bringing about inflammation via lymphocyte trafficking. ICAM-1 is essential for the transmigration of leukocytes out of blood vessels and into tissues, and is a marker of endothelial dysfunction leading to damaging vascular disorders in umbilical and placental vascular tissue of gestational pregnancies. ICAM-1 is the receptor for rhinoviruses (the cause of most common colds) and malaria, and plays an inflammatory role in ocular allergies.

Technical Datasheet:View
Protein:Inter-Cellular Adhesion Molecule 1
Research Area:Cell Biology, Costimulatory Molecules, Immunology, Innate Immunity, Neuroscience, Neuroscience Cell Markers, Stem Cell
Product Thumbnail
Mouse IgG1 Isotype Control [HKSP]
Clone HKSP
Isotype Mouse IgG1
Endotoxin Level Low Endotoxin
Learn More
Product Thumbnail
Mouse IgG1 Isotype Control [HKSP84]
Clone HKSP84
Isotype Mouse IgG1
Endotoxin Level Low Endotoxin
Learn More

Meet the team!


Shane Costigan

Shane Costigan

Territory Manager & Team Lead

Abdul Khadim

Abdul Khadim

Sales Executive

Related Products