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Anti-Human CD307e (FcRL5) In Vivo Antibody - Ultra Low Endotoxin (IVMB0375)

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SKU:
IVMB0375
Antibody Type:
Functional-Grade In Vivo Antibody
Disease Area:
Cancer
Clone:
509F6
Protein:
FcRL5
Isotype:
IgG2a k
Reactivity:
Human
Synonyms:
CD307e
CD307
BXMAS1
FCRH5
Fc receptor-like protein 5
IRTA2
Endotoxin Level:
Ultra Low Endotoxin
Host Species:
Mouse
Applications:
Blocking
FC
In Vivo
IP
€359 - €4,859

Description

Product Name:Anti-Human CD307e (FcRL5) In Vivo Antibody - Ultra Low Endotoxin
Product Code:IVMB0375
Size:1 mg, 5 mg, 25 mg, 50 mg, 100 mg
Clone:509F6
Protein:FcRL5
Product Type:Monoclonal Antibody
Synonyms:CD307e, CD307, BXMAS1, FCRH5, Fc receptor-like protein 5, IRTA2
Isotype:IgG2a k
Reactivity:Human
Applications:B, FC, In Vivo, IP
Formulation:This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Endotoxin Level:≤ 0.5 EU/mg as determined by the LAL method
Purity:≥98% monomer by analytical SEC ⋅ >95% by SDS Page
Product Preparation:Functional grade preclinical antibodies are manufactured in an animal free facility using in vitro cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Applications:B, FC, In Vivo, IP
Reactivity:Human
Host Species:Mouse
Specificity:Clone 50946 recognizes human FcRL5 within the first 3 Ig domains. Clone 50946 does not cross-react with FcRL4.
Antigen Distribution:FcRL5 is expressed on mature B cells and plasma cells.
Immunogen:Cells transfected with Human FcRL5.
Concentration:≥ 5.0 mg/ml
Endotoxin Level:≤ 0.5 EU/mg as determined by the LAL method
Formulation:This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Purity:≥98% monomer by analytical SEC ⋅ >95% by SDS Page
Preparation:Functional grade preclinical antibodies are manufactured in an animal free facility using in vitro cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Storage and Handling:Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.

FcRL5 antibody, 509F6, recognizes Fc receptor-like 5 (FcRL5), also known as immunoglobulin superfamily receptor translocation associated 2 (IRTA2), Fc receptor homolog 5 (FcRH5), and BXMAS1. FcRL5 is a 106 kDa type I transmembrane glycoprotein containing 9 Ig-like extracellular domains, a cytoplasmic ITAM-like consensus sequence, and two cytoplasmic ITIM-like sequences1. FcRL5 is found on most mature B cells, with the highest levels on naive and memory B cells and plasma cells1,2. FcRL5 is an IgG receptor and binds to all IgG isotypes3, resulting in the inhibition of BCR signaling through the recruitment of SH2 domain-containing tyrosine phosphatase 1 (SHP-1) after tyrosine phosphorylation of its two ITIMs4. B cell malignancies, including multiple myeloma, chronic lymphocytic leukemia, mantle cell lymphoma, and hairy cell leukemia, often exhibit aberrant FCRL5 expression, indicating FcRL5 as a potential biomarker or therapeutic target5-7.

Protein:FcRL5
Ligand/Receptor:Aggregated IgG
Pathogen Testing:To protect mouse colonies from infection by pathogens and to assure that experimental preclinical data is not affected by such pathogens, all of Assay Genie's Purified Functional Antibodies are tested and guaranteed to be negative for all pathogens in the IDEXX IMPACT I Mouse Profile.
Shipping:2-8°C
PubMed:FcRL5
NCBI Gene Bank ID:83416
UniProt:Q96RD9

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