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Anti-Human CD257 (BAFF) (Tabalumab) - Dylight® 488 Biosimilar (IVMB0445)

SKU:
IVMB0445
Antibody Type:
Dylight Biosimilar
Applications:
IHC
FC
Drug Development
Pharmacokinetics
Disease Area:
Cancer
$899

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Anti-Human CD257 (BAFF) (Tabalumab) - Dylight 488
SKU:IVMB0445
Size:100 µg
Antibody Type:Biosimilar Recombinant Human Monoclonal Antibody
Clone:Tabalumab
Target:BAFF
Isotype:Human IgG1κ
Host Species:Human
Reactivity:Human/Cynomolgus Monkey/Rabbit
Expression Host:HEK-293 Cells
FC Effector Activity:Active
Synonyms:Tabalumab, CD257, BAFF, TNFSF13b, BLYS
Product Concentration:0.2 mg/ml
Excitation Laser:Blue Laser (493 nm)
Immunogen:Original antibody was raised against soluble human BAFF.
Antigen Distribution:BAFF is expressed on various cell types including monocytes, dendritic cells and bone marrow stromal cells.
Formulation:This DyLight 488 conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Specificity:This non-therapeutic biosimilar antibody uses the same variable region sequence as the therapeutic antibody Tabalumab. Tabalumab neutralizes soluble human, cynomolgus monkey, and rabbit BAFF. Additionally, Tabalumab neutralizes membrane-bound BAFF. This product is for research use only.
Additional Reported Applications For Relevant Conjugates:NIPWBELISA

Tabalumab is a human monoclonal anti-B-cell activating factor (BAFF) antibody intended for the treatment of autoimmune diseases and B cell malignancies.1 BAFF is a membrane-bound, type II transmembrane protein that belongs to the tumor necrosis factor (TNF) ligand family and is the ligand for BR3, TACI, and BCMA. BAFF is an immunostimulant necessary for maintaining normal immunity. This cytokine has also been shown to play an important role in the proliferation and differentiation of B cells. An inadequate level of BAFF leads to immunodeficiency whilst an elevated level of BAFF causes unusually high antibody production that results in the development of autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis. Additionally, BAFF has been found in renal transplant biopsies with acute rejection.2 Furthermore, BAFF may be a mediator of food-related inflammation, and is associated with multiple dietary ailments including celiac disease, insulin resistance, diabetes, and obesity.3 Interestingly, it is suspected that BAFF may be involved in non-IgE-mediated reactions because there is no known correlation between BAFF and IgE.4 More research is needed to unlock the enormous therapeutic potential for BAFF antagonists. This cost-effective, research-grade Anti-Human CD257 (BAFF) (Tabalumab) utilizes the same variable regions from the therapeutic antibody Tabalumab making it ideal for research projects.

Ligand/Receptor:TACI, BCMA,APRIL ligand, BAFFR/BR3
State of Matter:Liquid
Regulatory Status:Research Use Only (RUO). Non-Therapeutic.
Storage and Handling:This DyLight 488 conjugate is stable when stored at 2-8°C.Do not freeze.
UniProt:Q9Y275
Research Area:Biosimilars

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