The HRH1 Polyclonal Antibody (CAB20159) is a valuable tool for researchers studying the histamine H1 receptor, an important G protein-coupled receptor involved in various physiological processes. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By targeting the HRH1 protein, researchers can detect and analyze its expression in a wide range of cell types, making it an ideal choice for investigations in immunology, pharmacology, and neuroscience.The histamine H1 receptor is known for its role in mediating allergic responses and regulating smooth muscle contraction, making it a key target for therapeutic interventions in conditions such as allergies, asthma, and insomnia.
Understanding the function and regulation of HRH1 is essential for developing novel treatments that target this receptor, offering potential solutions for managing allergic reactions and other related disorders. Overall, the HRH1 Polyclonal Antibody (CAB20159) provides researchers with a reliable tool to explore the biology of the histamine H1 receptor and its implications in various disease processes, paving the way for innovative therapeutic strategies.
Product Name:
HRH1 Rabbit Polyclonal Antibody
SKU:
CAB20159
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 250-340 of human HRH1 (NP_000852.1).
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. It has been associated with multiple processes, including memory and learning, circadian rhythm, and thermoregulation. It is also known to contribute to the pathophysiology of allergic diseases such as atopic dermatitis, asthma, anaphylaxis and allergic rhinitis. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Purification Method:
Affinity purification
Gene ID:
3269
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using HRH1 Rabbit pAb (CAB20159) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
