The Anti-HMGCS2 Antibody (CAB19232) is a valuable tool for researchers studying the HMGCS2 protein, an essential enzyme in the ketogenesis pathway. This antibody, produced in rabbits, exhibits high reactivity with human samples and is suitable for use in Western blot applications. By targeting the HMGCS2 protein, this antibody allows for accurate detection and analysis in various cell types, making it an ideal choice for investigations in metabolism, energy regulation, and related fields.HMGCS2, also known as 3-hydroxy-3-methylglutaryl-CoA synthase 2, plays a key role in the production of ketone bodies, which serve as an alternative energy source during periods of fasting or low carbohydrate intake.
Dysregulation of HMGCS2 has been linked to metabolic disorders such as diabetes and obesity, making it a valuable target for research aimed at understanding and treating these conditions. By elucidating the function of HMGCS2, researchers can gain insights into metabolic pathways and potentially identify novel therapeutic strategies.
Product Name:
HMGCS2 Rabbit Monoclonal Antibody
SKU:
CAB19232
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 409-508 of human HMGCS2 (P54868).
The protein encoded by this gene belongs to the HMG-CoA synthase family. It is a mitochondrial enzyme that catalyzes the first reaction of ketogenesis, a metabolic pathway that provides lipid-derived energy for various organs during times of carbohydrate deprivation, such as fasting. Mutations in this gene are associated with HMG-CoA synthase deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
3158
Clone Number:
ARC2390
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using HMGCS2 Rabbit mAb (CAB19232) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
