null

HLA-DRB4 Rabbit Monoclonal Antibody (CAB0439)

SKU:
CAB0439
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
HLA-DRB4
DR4
DRB4
HLA-DR4B
major histocompatibility complex
class II
DR beta 4
$167 - $503
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:HLA-DRB4 Rabbit Monoclonal Antibody
SKU:CAB0439
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 50-150 of human HLA-DRB4 (P13762).
Sequence:TERV WNLI RYIY NQEE YARY NSDL GEYQ AVTE LGRP DAEY WNSQ KDLL ERRR AEVD TYCR YNYG VVES FTVQ RRVQ PKVT VYPS KTQP LQHH NLLV CSVN G
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:1000
Synonyms:DR4; DRB4; HLA-DRB; HLA-DR4B; HLA-DRB4
Positive Sample:Raji
Conjugate:Unmodified
Cellular Localization:Cell membrane, Endoplasmic reticulum membrane, Endosome membrane, Golgi apparatus, Late endosome membrane, Lysosome membrane, Single-pass type I membrane protein, Trans-Golgi network membrane
Calculated MW:30kDa
Observed MW:30kDa

HLA-DRB4 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. There are multiple pseudogenes of this gene.

Purification Method:Affinity purification
Gene ID:3126
Clone Number:ARC2505
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Product ImageWestern blot analysis of extracts of Raji cells, using HLA-DRB4 antibody (CAB0439) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.

Related Products