HLA-DRB4 Rabbit Monoclonal Antibody (CAB0439)
- SKU:
- CAB0439
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- HLA-DRB4
- DR4
- DRB4
- HLA-DR4B
- major histocompatibility complex
- class II
- DR beta 4
Description
Product Name: | HLA-DRB4 Rabbit Monoclonal Antibody |
SKU: | CAB0439 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human HLA-DRB4 (P13762). |
Sequence: | TERV WNLI RYIY NQEE YARY NSDL GEYQ AVTE LGRP DAEY WNSQ KDLL ERRR AEVD TYCR YNYG VVES FTVQ RRVQ PKVT VYPS KTQP LQHH NLLV CSVN G |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | DR4; DRB4; HLA-DRB; HLA-DR4B; HLA-DRB4 |
Positive Sample: | Raji |
Conjugate: | Unmodified |
Cellular Localization: | Cell membrane, Endoplasmic reticulum membrane, Endosome membrane, Golgi apparatus, Late endosome membrane, Lysosome membrane, Single-pass type I membrane protein, Trans-Golgi network membrane |
Calculated MW: | 30kDa |
Observed MW: | 30kDa |
HLA-DRB4 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. There are multiple pseudogenes of this gene.
Purification Method: | Affinity purification |
Gene ID: | 3126 |
Clone Number: | ARC2505 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |