HLA-DRB1 Rabbit Monoclonal Antibody (CAB19835)
- SKU:
- CAB19835
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- DRB1
- HLA-DR1B
- HLA-DRB
- SS1
Description
Product Name: | HLA-DRB1 Rabbit Monoclonal Antibody |
SKU: | CAB19835 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human HLA-DRB1 (P01911). |
Sequence: | ARAA VDTY CRHN YGVV ESFT VQRR VQPK VTVY PSKT QPLQ HHNL LVCS VSGF YPGS IEVR WFLN GQEE KAGM VSTG LIQN GDWT FQTL VMLE TVPR SGEV Y |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 |
Synonyms: | SS1; DRB1; HLA-DRB; HLA-DR1B; HLA-DRB1 |
Positive Sample: | Raji |
Conjugate: | Unconjugated |
Cellular Localization: | Cell surface, External side of plasma membrane, Extracellular exosome, Extracellular space, Immunological synapse, Plasma membrane |
Calculated MW: | 30kDa |
Observed MW: | 35kDa |
HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and some alleles have increased frequencies associated with certain diseases or conditions. For example, DRB1*1302 has been related to acute and chronic hepatitis B virus persistence. There are multiple pseudogenes of this gene.
Purification Method: | Affinity purification |
Gene ID: | 3123 |
Clone Number: | ARC2360 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |