The Anti-HLA-DRB1 Antibody (CAB19835) is a powerful tool for researchers studying the HLA-DRB1 molecule, a key player in the immune system's recognition of foreign antigens. This antibody, produced through immunization of rabbits, exhibits high specificity and reactivity towards human samples, making it a reliable choice for various applications, including Western blot analysis.HLA-DRB1 is a major histocompatibility complex (MHC) class II molecule that plays a crucial role in antigen presentation to T cells, thereby initiating adaptive immune responses. Dysregulation of HLA-DRB1 expression or function has been linked to various autoimmune diseases, making it a focal point in research aimed at understanding immune system disorders.
The Anti-HLA-DRB1 Antibody (CAB19835) provides a valuable tool for investigating the role of HLA-DRB1 in immune responses and disease pathogenesis. Its ability to specifically target the HLA-DRB1 protein opens up opportunities for further exploration in fields such as immunology, autoimmunity, and transplantation studies. Researchers can rely on this antibody to facilitate their investigations into complex immune processes and potential therapeutic targets related to HLA-DRB1.
Product Name:
HLA-DRB1 Rabbit Monoclonal Antibody
SKU:
CAB19835
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human HLA-DRB1 (P01911).
Cell surface, External side of plasma membrane, Extracellular exosome, Extracellular space, Immunological synapse, Plasma membrane
Calculated MW:
30kDa
Observed MW:
35kDa
HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and some alleles have increased frequencies associated with certain diseases or conditions. For example, DRB1*1302 has been related to acute and chronic hepatitis B virus persistence. There are multiple pseudogenes of this gene.
Purification Method:
Affinity purification
Gene ID:
3123
Clone Number:
ARC2360
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using HLA-DRB1 Rabbit mAb (CAB19835) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
