The Anti-HLA-DQB1 Antibody (CAB20372) is a powerful tool for researchers studying the HLA-DQB1 molecule, a key component of the human immune system. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in a variety of research applications, including Western blot analysis.HLA-DQB1 plays a crucial role in immune recognition and response, particularly in the context of antigen presentation and T cell activation. By targeting this molecule with the Anti-HLA-DQB1 Antibody, researchers can gain valuable insights into the mechanisms underlying immune function and dysfunction.
This antibody is an essential tool for studies in immunology, autoimmune diseases, and transplantation research.By utilizing the Anti-HLA-DQB1 Antibody, researchers can expand their understanding of the immune system and potentially develop new therapeutic strategies for a variety of immune-related conditions. Don't miss this opportunity to enhance your research with this high-quality antibody.
Product Name:
HLA-DQB1 Rabbit Polyclonal Antibody
SKU:
CAB20372
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 33-127 of human HLA-DQB1 (NP_002114.3).
HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains six exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
3119
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from Raji cells, using HLA-DQB1 Rabbit pAb (CAB20372) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
