HLA DMB Rabbit Monoclonal Antibody (CAB0948)
- SKU:
- CAB0948
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- HLA-DMB
- D6S221E
- RING7
- major histocompatibility complex
- class II
- DM beta
- Research Area:
- Immunology
Description
Product Name: | HLA DMB Rabbit Monoclonal Antibody |
SKU: | CAB0948 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human HLA-DMB (P28068). |
Sequence: | MITF LPLL LGLS LGCT GAGG FVAH VEST CLLD DAGT PKDF TYCI SFNK DLLT CWDP EENK MAPC EFGV LNSL ANVL SQHL NQKD TLMQ RLRN GLQN CATH |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | RING7; D6S221E; HLA-DMB |
Positive Sample: | HT-29,Raji |
Conjugate: | Unmodified |
Cellular Localization: | Late endosome membrane, Lysosome membrane, Single-pass type I membrane protein. |
Calculated MW: | 29kDa |
Observed MW: | 29kDa |
HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.
Purification Method: | Affinity purification |
Gene ID: | 3109 |
Clone Number: | ARC2555 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |