The Anti-HIRA Antibody (CAB8892) is a valuable tool for researchers studying the HIRA protein, a key player in chromatin remodeling and DNA repair processes. This polyclonal antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the HIRA protein, this antibody allows for the detection and analysis of HIRA in various cell types, making it an essential tool for studies in molecular biology and cancer research.The HIRA protein is known for its involvement in histone deposition and nucleosome assembly, playing a crucial role in the maintenance of genomic stability and gene expression regulation.
Dysregulation of HIRA has been linked to various human diseases, including cancer and developmental disorders. Therefore, understanding the function and regulation of HIRA is essential for unraveling its implications in health and disease.Overall, the Anti-HIRA Antibody (CAB8892) offers researchers a reliable and specific tool for investigating the role of the HIRA protein in various biological processes, paving the way for the development of novel therapeutic strategies targeting HIRA-related pathways.
Product Name:
HIRA Rabbit Monoclonal Antibody
SKU:
CAB8892
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 550-675 of human HIRA (P54198).
extracellular exosome, nucleoplasm, nucleus, PML body
Calculated MW:
112kDa
Observed MW:
112kDa
This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development.
Purification Method:
Affinity purification
Gene ID:
7290
Clone Number:
ARC1341
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using HIRA antibody (CAB8892) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
