HIRA Rabbit Monoclonal Antibody (CAB8892)
- SKU:
- CAB8892
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- DGCR1
- TUP1
- TUPLE1
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
Product Name: | HIRA Rabbit Monoclonal Antibody |
SKU: | CAB8892 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 550-675 of human HIRA (P54198). |
Sequence: | PSVL TTPS KIEP MKAF DSRF TERS KATP GAPA LTSM TPTA VERL KEQN LVKE LRPR DLLE SSSD SDEK VPLA KASS LSKR KLEL EVET VEKK KKGR PRKD SRLM PVSL SVQS PAAL TAEK EAMC LS |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | TUP1; DGCR1; TUPLE1; HIRA |
Positive Sample: | HeLa,293T |
Conjugate: | Unconjugated |
Cellular Localization: | extracellular exosome, nucleoplasm, nucleus, PML body |
Calculated MW: | 112kDa |
Observed MW: | 112kDa |
This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development.
Purification Method: | Affinity purification |
Gene ID: | 7290 |
Clone Number: | ARC1341 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |