The HGD Monoclonal Antibody (CAB1400) is specifically designed for research on the HGD protein, which is involved in the metabolism of homogentisic acid. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in various applications, including Western blotting. By binding to the HGD protein, this antibody enables detection and analysis in different cell types, making it suitable for studies in metabolic disorders and related diseases. HGD, also known as homogentisate 1,2-dioxygenase, plays a crucial role in the breakdown of tyrosine and is essential for the proper functioning of the tyrosine degradation pathway.
Mutations in the HGD gene can lead to alkaptonuria, a rare genetic disorder characterized by the accumulation of homogentisic acid in the body. Research on HGD is important for understanding the molecular mechanisms underlying metabolic disorders and developing targeted therapies for individuals affected by these conditions. Overall, the HGD Monoclonal Antibody (CAB1400) provides a valuable tool for scientists and researchers studying the role of HGD in metabolism and related diseases, offering insights that may contribute to the development of novel treatments and interventions in the future.
Product Name:
HGD Rabbit Monoclonal Antibody
SKU:
CAB1400
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 346-445 of human HGD (Q93099).
This gene encodes the enzyme homogentisate 1,2 dioxygenase. This enzyme is involved in the catabolism of the amino acids tyrosine and phenylalanine. Mutations in this gene are the cause of the autosomal recessive metabolism disorder alkaptonuria.
Purification Method:
Affinity purification
Gene ID:
3081
Clone Number:
ARC2561
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using HGD antibody (CAB1400) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
