The Anti-HFE Antibody (CAB0937) is a highly specific and sensitive tool for research involving the HFE protein, a key player in iron metabolism regulation. This antibody, generated in rabbits, exhibits strong reactivity with human samples and is validated for use in various applications such as Western blot and immunohistochemistry. By targeting the HFE protein, this antibody enables precise detection and analysis of HFE expression in a variety of cell types, making it an ideal choice for studies in the fields of molecular biology and metabolic disorders.The HFE protein, also known as the major histocompatibility complex class I-like protein, plays a crucial role in controlling iron absorption and storage within the body.
Dysregulation of HFE expression has been linked to various disorders such as hereditary hemochromatosis, a condition characterized by excessive iron accumulation in tissues. Investigating the function of HFE is essential for understanding the mechanisms underlying iron homeostasis and developing potential therapies for related diseases.Overall, the Anti-HFE Antibody (CAB0937) offers researchers a reliable tool to explore the role of HFE in iron metabolism regulation and related pathological conditions. Its high specificity and sensitivity make it a valuable asset for studies aiming to unravel the complexities of iron homeostasis and advance our knowledge of metabolic disorders.
Product Name:
HFE Rabbit Monoclonal Antibody
SKU:
CAB0937
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 249-348 of human HFE (Q30201).
The protein encoded by this gene is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin (beta2M). It is thought that this protein functions to regulate iron absorption by regulating the interaction of the transferrin receptor with transferrin. The iron storage disorder, hereditary haemochromatosis, is a recessive genetic disorder that results from defects in this gene.
Purification Method:
Affinity purification
Gene ID:
3077
Clone Number:
ARC2554
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using HFE antibody (CAB0937) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
