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Anti-HES5 Antibody (CAB9768)

SKU:
CAB9768
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
bHLHb38
Research Area:
Developmental Biology
€139 - €419
Frequently bought together:

Description

Anti-HES5 Antibody (CAB9768)

The HES5 Polyclonal Antibody (CAB9768) is a valuable tool for researchers studying the HES5 protein, a transcription factor involved in various biological processes, including cell differentiation and development. This antibody, derived from rabbits, demonstrates high reactivity with human samples and is suitable for use in Western blot assays.HES5 is known for its role in regulating neuronal differentiation and self-renewal of neural stem cells, making it a key player in the field of neuroscience and stem cell research.

By targeting the HES5 protein, researchers can gain insights into the molecular mechanisms underlying these processes, paving the way for innovative therapies for neurological disorders and conditions affecting neural regeneration.With its specificity and sensitivity, the HES5 Polyclonal Antibody (CAB9768) is a valuable tool for scientists looking to explore the functions of HES5 in various biological contexts, offering new avenues for therapeutic interventions and potential drug targets.

Product Name:HES5 Rabbit mAb
Product Code:CAB9768
Size:20uL, 50uL, 100uL
Synonyms:bHLHb38
Applications:WB, IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human HES5
Applications:WB, IHC
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse brain, Mouse spleen, Rat brain, Rat spleen
Immunogen:A synthesized peptide derived from human HES5
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:388585
Uniprot:Q5TA89
Cellular Location:Nucleus
Calculated MW:18kDa
Observed MW:18kDa
UniProt Protein Function:HES5: Transcriptional repressor of genes that require a bHLH protein for their transcription.
UniProt Protein Details:

Protein type:Transcription regulation; Cell development/differentiation

Chromosomal Location of Human Ortholog: 1p36.32

Cellular Component: nucleoplasm

Biological Process: astrocyte differentiation; auditory receptor cell differentiation; brain development; camera-type eye development; cartilage development; cell adhesion; cell maturation; chondrocyte differentiation; glial cell fate commitment; myelination in the central nervous system; negative regulation of astrocyte differentiation; negative regulation of neuron differentiation; negative regulation of oligodendrocyte differentiation; negative regulation of transcription from RNA polymerase II promoter; neural tube development; Notch signaling pathway; oligodendrocyte development; positive regulation of BMP signaling pathway; positive regulation of cell proliferation; positive regulation of JAK-STAT cascade; positive regulation of smooth muscle cell proliferation; positive regulation of transcription, DNA-dependent; positive regulation of tyrosine phosphorylation of Stat3 protein; protein complex assembly; regulation of cell differentiation; regulation of myelination; regulation of neurogenesis; smoothened signaling pathway; telencephalon development

NCBI Summary:This gene encodes a member of a family of basic helix-loop-helix transcriptional repressors. The protein product of this gene, which is activated downstream of the Notch pathway, regulates cell differentiation in multiple tissues. Disruptions in the normal expression of this gene have been associated with developmental diseases and cancer. [provided by RefSeq, Dec 2008]
UniProt Code:Q5TA89
NCBI GenInfo Identifier:74745795
NCBI Gene ID:388585
NCBI Accession:Q5TA89.1
UniProt Secondary Accession:Q5TA89,B9DI85,
UniProt Related Accession:Q5TA89
Molecular Weight:18,226 Da
NCBI Full Name:Transcription factor HES-5
NCBI Synonym Full Names:hes family bHLH transcription factor 5
NCBI Official Symbol:HES5  
NCBI Official Synonym Symbols:bHLHb38  
NCBI Protein Information:transcription factor HES-5
UniProt Protein Name:Transcription factor HES-5
UniProt Synonym Protein Names:Class B basic helix-loop-helix protein 38; bHLHb38; Hairy and enhancer of split 5
Protein Family:Transcription factor
UniProt Gene Name:HES5  
UniProt Entry Name:HES5_HUMAN

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