The Anti-HER2 Chimeric Recombinant Rabbit Monoclonal Antibody (HDAB0252) is a cutting-edge research tool specifically designed for the detection of HER2, a cell surface receptor associated with cancer. This antibody, generated using advanced technology, offers high sensitivity and specificity in identifying HER2 in human samples. Validated for use in various applications such as immunohistochemistry and flow cytometry, it allows for precise detection and analysis of HER2 expression in different types of cancer cells.HER2, also known as human epidermal growth factor receptor 2, plays a crucial role in promoting cell growth and survival in cancer. Overexpression of HER2 is commonly observed in breast and other types of cancers, making it a significant biomarker for tumor aggressiveness and therapeutic targeting.
Understanding the expression and function of HER2 is essential for developing targeted therapies and personalized treatment strategies for HER2-positive cancers.The Anti-HER2 Chimeric Recombinant Rabbit Monoclonal Antibody (HDAB0252) offers researchers a powerful tool to study HER2 biology and explore potential therapeutic interventions for HER2-driven cancers. Its superior performance and reliability make it an invaluable addition to research efforts aimed at improving cancer diagnosis and treatment outcomes.
SKU:
HDAB0252
Size:
100 µg
Clonality:
Monoclonal
Clone:
DMC369
Synonyms:
ERBB2,CD340,HER-2/neu,HER2,MLN19,NEU,NGL,TKR1
Applications:
Flow Cyt
Recommended Dilution:
Flow Cyt 1:100
Host Species:
Rabbit
Isotype:
Rabbit/Human Fc chimeric IgG1
Reactivity:
Human
Purification Method:
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
