The Anti-HDAC6 Antibody (CAB3572) is a valuable tool for researchers studying HDAC6, a histone deacetylase enzyme involved in regulating gene expression and cell function. This antibody, generated in rabbits, is highly specific and reacts strongly with HDAC6 in human samples. It has been validated for use in Western blotting applications, allowing for the detection and analysis of HDAC6 levels in various cell types.HDAC6 is known for its roles in various cellular processes, including cell proliferation, migration, and survival. Dysregulation of HDAC6 has been implicated in numerous diseases, making it a promising target for therapeutic intervention.
By studying HDAC6 expression and activity, researchers can gain insights into its role in cancer, neurodegenerative disorders, and inflammatory conditions.Overall, the Anti-HDAC6 Antibody (CAB3572) is a reliable tool for researchers interested in investigating the biological functions of HDAC6 and its potential implications in disease pathology. Its specificity and sensitivity make it a valuable asset for studies in cell biology, cancer biology, and drug discovery.
Product Name:
HDAC6 Rabbit Monoclonal Antibody
SKU:
CAB3572
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human HDAC6 (Q9UBN7).
WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells
Synonyms:
HD6; JM21; CPBHM; PPP1R90; HDAC6
Positive Sample:
HeLa,Hep G2
Conjugate:
Unconjugated
Cellular Localization:
Axon cytoplasm, Caveola, Centrosome, Ciliary basal body, Cytoplasm, Cytosol, Histone deacetylase complex, Multivesicular body, Nucleoplasm, Nucleus, Perinuclear region of cytoplasm
Calculated MW:
131kDa
Observed MW:
160kDa
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription.
Purification Method:
Affinity purification
Gene ID:
10013
Clone Number:
ARC0805
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using HDAC6 Rabbit mAb (CAB3572) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
