The Anti-HBG1 Antibody (CAB0704) is a high-quality polyclonal antibody specifically designed for research involving HBG1, a protein involved in hemoglobin synthesis. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been extensively validated for use in Western blot applications. By binding to the HBG1 protein, this antibody allows for the accurate detection and analysis of HBG1 in a variety of cell types, making it an essential tool for studies in hematology and related fields.HBG1 is a critical component of hemoglobin, the protein responsible for transporting oxygen in the blood. Understanding the function and regulation of HBG1 is vital for research into hematological disorders, such as anemia and sickle cell disease.
By targeting HBG1, researchers can gain insights into the molecular mechanisms underlying these conditions and identify potential therapeutic targets for their treatment.Overall, the Anti-HBG1 Antibody (CAB0704) offers researchers a reliable and effective tool for investigating the role of HBG1 in hemoglobin synthesis and related processes. Its specificity and sensitivity make it indispensable for studies aiming to deepen our understanding of hematology and its implications for human health.
Product Name:
HBG1/2 Rabbit Monoclonal Antibody
SKU:
CAB0704
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human HBG1 (P69891).
Sequence:
MGHF TEED KATI TSLW GKVN VEDA GGET LGRL LVVY PWTQ RFFD SFGN LSSA SAIM GNPK VKAH GKKV LTSL GDAI KHLD DLKG TFAQ LSEL HCDK LHVD
The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'. [provided by RefSeq, Jul 2008]
Purification Method:
Affinity purification
Gene ID:
3047/3048
Clone Number:
ARC1838
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse kidney , using HBG1/2 Rabbit mAb (CAB0704) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
