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fetal hemoglobin Rabbit Monoclonal Antibody (CAB0670)

SKU:
CAB0670
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
HBG-T2
HBGA
HBGR
HSGGL1
PRO2979
$167 - $503
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:fetal hemoglobin Rabbit Monoclonal Antibody
SKU:CAB0670
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 68-147 of human HBG1 (P69891).
Sequence:VLTS LGDA IKHL DDLK GTFA QLSE LHCD KLHV DPEN FKLL GNVL VTVL AIHF GKEF TPEV QASW QKMV TAVA SALS SRYH
Tested Applications:WB IF/ICC ELISA
Recommended Dilution:WB,1:100 - 1:500 IF/ICC,1:50 - 1:200
Synonyms:HBG-T2; HBGA; HBGR; HSGGL1; PRO2979; HBG1
Positive Sample:K-562
Conjugate:Unconjugated
Cellular Localization:cytosol, hemoglobin complex
Calculated MW:16kDa
Observed MW:12kDa

The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'. [provided by RefSeq, Jul 2008]

Purification Method:Affinity purification
Gene ID:3047/3048
Clone Number:ARC1837
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Product ImageWestern blot analysis of extracts of K-562 cells, using HBG1 antibody (CAB0670) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.

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