The Anti-HBEGF Chimeric Recombinant Rabbit Monoclonal Antibody (HDAB0323) is a cutting-edge tool for research involving HBEGF, a growth factor involved in various cellular processes, including cell proliferation and migration. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it an excellent choice for use in Western blot applications. By targeting the HBEGF protein, this antibody enables precise detection and analysis in a variety of cell types, making it well-suited for studies in molecular biology and cancer research.HBEGF, also known as heparin-binding EGF-like growth factor, plays a crucial role in promoting cell growth and survival in both normal and cancerous cells.
Its dysregulation has been linked to various diseases, including cancer, cardiovascular disorders, and inflammatory conditions. By understanding the function of HBEGF and its signaling pathways, researchers can develop targeted therapies to treat these diseases effectively.In summary, the Anti-HBEGF Chimeric Recombinant Rabbit Monoclonal Antibody (HDAB0323) is a valuable tool for investigating the role of HBEGF in various cellular processes and disease states. Its high specificity and sensitivity make it an essential resource for researchers seeking to unravel the complexities of HBEGF signaling and develop new therapeutic strategies.
SKU:
HDAB0323
Size:
100 µg
Clonality:
Monoclonal
Clone:
DMC500
Synonyms:
DTR; DTS; DTSF; HEGFL
Applications:
Flow Cyt
Recommended Dilution:
Flow Cyt 1:100
Host Species:
Rabbit
Isotype:
Rabbit/Human Fc chimeric IgG1
Reactivity:
Human
Purification Method:
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.[UniProtKB/Swiss-Prot Function]
