The Anti-Guanylyl Cyclase Beta 1 (GUCY1B3) Antibody (CAB3687) is a valuable tool for researchers studying the GUCY1B3 protein, which plays a crucial role in the regulation of cyclic GMP (cGMP) signaling pathways. This polyclonal antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications.GUCY1B3 is a key component of the guanylyl cyclase enzyme complex, which is involved in the conversion of GTP to cGMP. Dysregulation of cGMP signaling has been implicated in a variety of diseases, including cardiovascular disorders, neurological conditions, and cancer.
By targeting GUCY1B3, researchers can gain insights into the mechanisms underlying these diseases and potentially identify new therapeutic targets.This antibody enables the detection and analysis of GUCY1B3 in various cell types, making it a versatile tool for research in pharmacology, biochemistry, and molecular biology. By understanding the role of GUCY1B3 in cGMP signaling, researchers can uncover new pathways for drug development and therapeutic interventions.
This gene encodes the beta subunit of the soluble guanylate cyclase (sGC), which catalyzes the conversion of GTP (guanosine triphosphate) to cGMP (cyclic guanosine monophosphate). The encoded protein contains an HNOX domain, which serves as a receptor for ligands such as nitric oxide, oxygen and nitrovasodilator drugs. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
2983
Clone Number:
ARC2071
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using Guanylyl Cyclase beta 1 (GUCY1B3) (GUCY1B3) Rabbit mAb (CAB3687) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.
