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Anti-GRK3 Antibody (CAB9163)

SKU:
CAB9163
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
ADRBK2
BARK2
Research Area:
Cell Biology
€139 - €419
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Description

Anti-GRK3 Antibody (CAB9163)

The GRK3 Polyclonal Antibody (CAB9163) is a valuable tool for researchers studying G protein-coupled receptor kinase 3 (GRK3), an enzyme involved in the regulation of G protein-coupled receptors. This antibody is raised in rabbits and exhibits high reactivity with human samples, making it ideal for use in Western blot applications.GRK3 is known to play a critical role in various physiological processes, including signal transduction, cell differentiation, and apoptosis. Dysregulation of GRK3 has been implicated in several diseases, making it a promising therapeutic target for conditions such as cancer, cardiovascular disease, and neurological disorders.

By detecting and analyzing the GRK3 protein in different cell types, this antibody allows researchers to gain valuable insights into the function and regulation of GRK3. Its specificity and sensitivity make it a reliable tool for studies in molecular biology, pharmacology, and drug development. Unlock the potential of GRK3 research with the CAB9163 antibody from AssayGenie.

Product Name:GRK3 Rabbit mAb
Product Code:CAB9163
Size:20uL, 50uL, 100uL
Synonyms:ADRBK2, BARK2
Applications:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human GRK3
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:Jurkat, SH-SY5Y
Immunogen:A synthesized peptide derived from human GRK3
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:157
Uniprot:P35626
Calculated MW:80kDa
Observed MW:80KDa
UniProt Protein Function:GRK3: Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
UniProt Protein Details:

Protein type:Protein kinase, Ser/Thr (non-receptor); Protein kinase, AGC; EC 2.7.11.15; Kinase, protein; AGC group; GRK family; BARK subfamily

Chromosomal Location of Human Ortholog: 22q12.1

Molecular Function:ATP binding; beta-adrenergic receptor kinase activity; G-protein coupled receptor kinase activity; protein kinase activity

Biological Process: protein amino acid phosphorylation; receptor internalization; signal transduction

NCBI Summary:The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function. [provided by RefSeq, Jul 2008]
UniProt Code:P35626
NCBI GenInfo Identifier:116241253
NCBI Gene ID:157
NCBI Accession:P35626.2
UniProt Secondary Accession:P35626,Q9UGW9,
UniProt Related Accession:P35626
Molecular Weight:79,710 Da
NCBI Full Name:Beta-adrenergic receptor kinase 2
NCBI Synonym Full Names:adrenergic, beta, receptor kinase 2
NCBI Official Symbol:ADRBK2  
NCBI Official Synonym Symbols:GRK3; BARK2  
NCBI Protein Information:beta-adrenergic receptor kinase 2
UniProt Protein Name:Beta-adrenergic receptor kinase 2
UniProt Synonym Protein Names:G-protein-coupled receptor kinase 3
Protein Family:Beta-adrenergic receptor kinase
UniProt Gene Name:ADRBK2  
UniProt Entry Name:ARBK2_HUMAN

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