GNE Monoclonal Antibody (CAB20978)
- SKU:
- CAB20978
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
Frequently bought together:
Description
Product Name: | GNE Monoclonal Antibody |
SKU: | CAB20978 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 623-722 of human GNE (Q9Y223). |
Sequence: | GALH LIQA AKLG NAKA QSIL RTAG TALG LGVV NILH TMNP SLVI LSGV LASH YIHI VKDV IRQQ ALSS VQDV DVVV SDLV DPAL LGAA SMVL DYTT RRIY |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | NM; DMRV; IBM2; Uae1; GLCNE; GNE |
Positive Sample: | HepG2,A-549,Jurkat,K-562,Mouse liver,Rat liver |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm. |
Calculated MW: | 79kDa |
Observed MW: | 75kDa |
The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alternative splicing of this gene results in transcript variants encoding different isoforms.
Purification Method: | Affinity purification |
Gene ID: | 10020 |
Clone Number: | ARC2970 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |