The Anti-GLYT2 Antibody (CAB20931) is a highly specific tool for researchers studying the glycine transporter 2 (GLYT2) protein, which plays a crucial role in inhibitory neurotransmission by regulating the uptake of glycine in the nervous system. This antibody, raised in rabbits, is optimized for use in various applications such as Western blot and immunohistochemistry.GLYT2 is known to be essential for maintaining the balance of neurotransmitters in the central nervous system, making it a promising target for investigating neurological disorders and developing potential therapeutics. By targeting the GLYT2 protein, researchers can gain insights into its function and potential implications in conditions such as epilepsy, schizophrenia, and neuropathic pain.
With its high reactivity and specificity towards GLYT2, the Anti-GLYT2 Antibody (CAB20931) offers a valuable tool for elucidating the role of this important protein in neurological function and pathology. Researchers can use this antibody to study GLYT2 expression levels, localization, and interactions in various experimental settings, further advancing our understanding of neurotransmission and potential therapeutic targets in neurological disorders.
Product Name:
Glyt2 Monoclonal Antibody
SKU:
CAB20931
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 250-350 of human Glyt2 (Q9Y345).
This gene encodes a sodium- and chloride-dependent glycine neurotransmitter transporter. This integral membrane glycoprotein is responsible for the clearance of extracellular glycine during glycine-mediated neurotransmission. This protein is found in glycinergic axons and maintains a high presynaptic pool of neurotransmitter at glycinergic synapses. Mutations in this gene cause hyperekplexia; a heterogenous neurological disorder characterized by exaggerated startle responses and neonatal apnea. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
9152
Clone Number:
ARC2912
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Glyt2 antibody (CAB20931) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
