The GJA8 Polyclonal Antibody (CAB19312) is a valuable tool for researchers studying GJA8, a key protein involved in cell-to-cell communication in various tissues, particularly in the lens of the eye. This antibody, produced in rabbits, demonstrates high specificity and sensitivity for detecting GJA8 in human samples, making it ideal for applications such as Western blotting.GJA8, also known as connexin 50, is essential for maintaining lens transparency and proper functioning of the eye.
Mutations in the GJA8 gene have been linked to cataracts and other visual impairments, highlighting the importance of studying this protein in disease contexts. By using the GJA8 Polyclonal Antibody, researchers can gain insights into the role of GJA8 in normal lens development and function, as well as its potential involvement in ophthalmic disorders. This antibody is a valuable tool for advancing research in ophthalmology and related fields.
Product Name:
GJA8 Rabbit Polyclonal Antibody
SKU:
CAB19312
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 234-433 of human GJA8 (NP_005258.2).
This gene encodes a transmembrane connexin protein that is necessary for lens growth and maturation of lens fiber cells. The encoded protein is a component of gap junction channels and functions in a calcium and pH-dependent manner. Mutations in this gene have been associated with zonular pulverulent cataracts, nuclear progressive cataracts, and cataract-microcornea syndrome.
Purification Method:
Affinity purification
Gene ID:
2703
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Raji cells, using GJA8 Rabbit pAb (CAB19312) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
