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Gemin 2 Rabbit Monoclonal Antibody (CAB19254)

SKU:
CAB19254
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
GEMIN2
SIP1
SIP1-delta
gem-associated protein 2
Research Area:
Epigenetics and Nuclear Signaling
$167 - $503
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Gemin 2 Rabbit Monoclonal Antibody
SKU:CAB19254
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Gemin 2 (O14893).
Sequence:MRRA ELAG LKTM AWVP AESA VEEL MPRL LPVE PCDL TEGF DPSV PPRT PQEY LRRV QIEA AQCP DVVV AQID PKKL KRKQ SVNI SLSG CQPA PEGY SPTL
Tested Applications:WB IHC-P ELISA
Recommended Dilution:WB,1:500 - 1:1000 IHC-P,1:50 - 1:200
Synonyms:SIP1; SIP1-delta; Gemin 2
Positive Sample:U-2 OS,HeLa,MCF7,Mouse testis,Mouse thymus,Rat testis,Rat pancreas
Conjugate:Unconjugated
Cellular Localization:Cytoplasm, Nucleus, gem.
Calculated MW:32kDa
Observed MW:32kDa

This gene encodes one of the proteins found in the SMN complex, which consists of several gemin proteins and the protein known as the survival of motor neuron protein. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. This protein interacts directly with the survival of motor neuron protein and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration.

Purification Method:Affinity purification
Gene ID:8487
Clone Number:ARC2419
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using Gemin 2 Rabbit mAb (CAB19254) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.

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