The Anti-Gemin-2 Antibody (CAB19254) is a valuable tool for researchers studying RNA processing and splicing mechanisms. Gemin-2 is a critical component of the SMN complex, which is essential for the assembly of spliceosomal small nuclear ribonucleoproteins (snRNPs). This antibody, raised in rabbits, exhibits high specificity and sensitivity towards human samples and is validated for use in various applications, including Western blotting and immunofluorescence.Gemin-2 is involved in the assembly and maturation of snRNPs, which play a crucial role in pre-mRNA splicing. Dysregulation of splicing mechanisms has been implicated in various diseases, including spinal muscular atrophy (SMA) and certain types of cancer.
Therefore, by studying Gemin-2 and its interactions with other components of the SMN complex, researchers can gain valuable insights into the molecular mechanisms underlying these diseases.The Anti-Gemin-2 Antibody is a versatile tool for investigating the function of Gemin-2 in RNA processing and splicing pathways. Its high specificity and sensitivity make it suitable for a wide range of research applications, making it an essential component of any immunology or cancer research lab.
Product Name:
Gemin 2 Rabbit Monoclonal Antibody
SKU:
CAB19254
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Gemin 2 (O14893).
This gene encodes one of the proteins found in the SMN complex, which consists of several gemin proteins and the protein known as the survival of motor neuron protein. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. This protein interacts directly with the survival of motor neuron protein and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration.
Purification Method:
Affinity purification
Gene ID:
8487
Clone Number:
ARC2419
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using Gemin 2 Rabbit mAb (CAB19254) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
