The Anti-GDNF Chimeric Recombinant Rabbit Monoclonal Antibody (HDAB0321) is a cutting-edge tool for researchers studying GDNF, a critical neurotrophic factor involved in the survival and function of various neuronal populations. This antibody, developed using advanced recombinant technology, exhibits high specificity and sensitivity for detecting GDNF in a variety of biological samples.With its chimeric structure, the antibody combines the superior binding affinity of rabbit monoclonal antibodies with the enhanced stability and consistency of recombinant antibodies.
This unique design ensures reliable and reproducible results in experiments such as immunohistochemistry, immunofluorescence, and flow cytometry.GDNF is known for its neuroprotective and neuroregenerative properties, making it a promising target for research in neurobiology and neurodegenerative diseases. By using the Anti-GDNF Chimeric Recombinant Rabbit Monoclonal Antibody, researchers can explore the role of GDNF in various cellular processes, paving the way for new insights and potential therapeutic strategies.
SKU:
HDAB0321
Size:
100 µg
Clonality:
Monoclonal
Clone:
DMC498
Synonyms:
ATF; ATF1; ATF2; HFB1-GDNF; HSCR3
Applications:
Flow Cyt
Recommended Dilution:
Flow Cyt 1:100
Host Species:
Rabbit
Isotype:
Rabbit/Human Fc chimeric IgG1
Reactivity:
Human
Purification Method:
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The recombinant form of this protein, a highly conserved neurotrophic factor, was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. This protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Mutations in this gene may be associated with Hirschsprung disease and Tourette syndrome. This gene encodes multiple protein isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016]
