The Anti-GDF15 Chimeric Recombinant Rabbit Monoclonal Antibody (HDAB0300) is a cutting-edge tool for researchers studying proteins involved in various cellular processes, particularly GDF15. This antibody, generated using advanced technology, offers high specificity and sensitivity when detecting GDF15 in human samples.GDF15, a member of the TGF-beta superfamily, is known for its role in regulating cell growth, inflammation, and metabolism. Research on GDF15 has linked its expression to various diseases, making it a promising target for therapeutic interventions. The Anti-GDF15 Antibody binds specifically to GDF15, allowing for accurate detection and quantification in different experimental settings.
This antibody is validated for use in techniques such as Western blotting, immunofluorescence, and immunohistochemistry, providing flexibility for diverse research applications. Its reliability and consistency make it an invaluable tool for investigating the functions of GDF15 in health and disease, particularly in the fields of cancer biology and metabolic disorders. By utilizing this antibody, researchers can gain valuable insights into the role of GDF15 and its potential as a diagnostic marker or therapeutic target.
SKU:
HDAB0300
Size:
100 µg
Clonality:
Monoclonal
Clone:
DMC474
Synonyms:
GDF-15; MIC-1; MIC1; NAG-1; PDF; PLAB; PTGFB
Applications:
Flow Cyt
Recommended Dilution:
Flow Cyt 1:100
Host Species:
Rabbit
Isotype:
Rabbit/Human Fc chimeric IgG1
Reactivity:
Human
Purification Method:
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The protein is expressed in a broad range of cell types, acts as a pleiotropic cytokine and is involved in the stress response program of cells after cellular injury. Increased protein levels are associated with disease states such as tissue hypoxia, inflammation, acute injury and oxidative stress. [provided by RefSeq, Aug 2016]
