GAD67/GAD1 Rabbit Monoclonal Antibody (CAB1475)
- SKU:
- CAB1475
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- CPSQ1
- GAD
- SCP
- Research Area:
- Neuroscience
Frequently bought together:
Description
Product Name: | GAD67/GAD1 Rabbit Monoclonal Antibody |
SKU: | CAB1475 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human GAD67/GAD1 (Q99259). |
Sequence: | MASS TPSS SATS SNAG ADPN TTNL RPTT YDTW CGVA HGCT RKLG LKIC GFLQ RTNS LEEK SRLV SAFK ERQS SKNL LSCE NSDR DARF RRTE TDFS NLFA |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | GAD; SCP; CPSQ1; DEE89; GAD67/GAD1 |
Positive Sample: | 293T,U-251MG,Mouse lung,Rat lung |
Conjugate: | Unconjugated |
Cellular Localization: | Axon terminus, Cell cortex, Cytoplasm, GABA-ergic synapse, Inhibitory synapse, Plasma membrane, Presynaptic active zone |
Calculated MW: | 67kDa |
Observed MW: | 70kDa |
This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form.
Purification Method: | Affinity purification |
Gene ID: | 2571 |
Clone Number: | ARC1879 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |