GABA A Receptor beta 1 (GABRB1) Rabbit Monoclonal Antibody (CAB19681)
The Anti-GABA-A Receptor beta 1 (GABRB1) Antibody (CAB19681) is a valuable tool for researchers studying the GABA-A receptor, a key player in neurotransmission and synaptic inhibition in the brain. This polyclonal antibody, raised in rabbits, has been rigorously tested and validated for use in Western blot applications, specifically targeting the GABRB1 protein.GABA-A receptors are the major inhibitory neurotransmitter receptors in the central nervous system and play a crucial role in regulating neuronal excitability. Dysfunction of these receptors has been implicated in various neurological disorders such as epilepsy, anxiety, and insomnia. The GABRB1 subunit is an essential component of the GABA-A receptor complex, and understanding its expression and function is essential for elucidating the molecular mechanisms underlying these conditions.
With its high specificity and sensitivity, the CAB19681 antibody allows for accurate detection and analysis of GABRB1 in different cell types and tissues, making it an invaluable tool for neuroscientists and researchers interested in studying the role of GABA-A receptors in health and disease. By targeting the GABRB1 subunit, this antibody provides new insights into the complex workings of the GABAergic system and opens up potential avenues for developing novel therapeutic strategies for neurologic and psychiatric disorders.
Product Name:
GABA A Receptor beta 1 (GABRB1) Rabbit Monoclonal Antibody
SKU:
CAB19681
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 350-450 of human GABA A Receptor beta 1 (GABRB1) (NP_000803.2).
The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 1 subunit. It is mapped to chromosome 4p12 in a cluster comprised of genes encoding alpha 4, alpha 2 and gamma 1 subunits of the GABA A receptor. Alteration of this gene is implicated in the pathogenetics of schizophrenia.
Purification Method:
Affinity purification
Gene ID:
2560
Clone Number:
ARC2229
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using GABA A Receptor beta 1 (GABRB1) (GABRB1) Rabbit mAb (CAB19681) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
