The GAA Polyclonal Antibody (CAB19234) is a valuable tool for research involving the GAA protein, a key enzyme involved in the breakdown of glycogen. This antibody, raised in rabbits, is highly specific for human GAA samples and is validated for use in various applications, including Western blot and immunohistochemistry.GAA plays a crucial role in glycogen metabolism, specifically in lysosomes where it breaks down glycogen into glucose. Mutations in the GAA gene can lead to glycogen storage diseases, where glycogen accumulates in various tissues causing damage and dysfunction.
Understanding the expression and activity of GAA is essential for studying these diseases and developing potential therapies.With its high reactivity and specificity, the GAA Polyclonal Antibody is an ideal tool for researchers studying glycogen metabolism, lysosomal disorders, and related conditions. Its ability to detect GAA protein in cell samples makes it a valuable resource for investigations into the role of GAA in health and disease.
Product Name:
GAA Rabbit Monoclonal Antibody
SKU:
CAB19234
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human GAA (P10253).
This gene encodes lysosomal alpha-glucosidase, which is essential for the degradation of glycogen to glucose in lysosomes. The encoded preproprotein is proteolytically processed to generate multiple intermediate forms and the mature form of the enzyme. Defects in this gene are the cause of glycogen storage disease II, also known as Pompe's disease, which is an autosomal recessive disorder with a broad clinical spectrum. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
2548
Clone Number:
ARC2392
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using GAA Rabbit mAb (CAB19234) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
