The Fukutin Polyclonal Antibody (CAB1385) is a valuable tool for research involving Fukutin, a key protein involved in the glycosylation of alpha-dystroglycan in the process of protein glycosylation. This antibody, raised in rabbits, exhibits high specificity and sensitivity towards human samples, making it suitable for a variety of applications such as immunohistochemistry and Western blotting.Fukutin is essential for the proper function of alpha-dystroglycan, a protein that plays a crucial role in maintaining muscle integrity and function. Mutations in the Fukutin gene have been associated with congenital muscular dystrophies and other neuromuscular disorders, emphasizing the importance of studying this protein in disease pathology.
By utilizing the Fukutin Polyclonal Antibody, researchers can gain insights into the expression and localization of Fukutin in different cell types and tissues, facilitating further investigations into its role in normal physiology and disease development. This antibody is a valuable tool for studies in muscle biology, glycobiology, and neurological disorders, providing a deeper understanding of Fukutin's functions and potential therapeutic implications.
Product Name:
Fukutin Rabbit Monoclonal Antibody
SKU:
CAB1385
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 362-461 of human Fukutin (O75072).
Golgi apparatus membrane, Single-pass type II membrane protein.
Calculated MW:
54kDa
Observed MW:
54kDa
The protein encoded by this gene is a putative transmembrane protein that is localized to the cis-Golgi compartment, where it may be involved in the glycosylation of alpha-dystroglycan in skeletal muscle. The encoded protein is thought to be a glycosyltransferase and could play a role in brain development. Defects in this gene are a cause of Fukuyama-type congenital muscular dystrophy (FCMD), Walker-Warburg syndrome (WWS), limb-girdle muscular dystrophy type 2M (LGMD2M), and dilated cardiomyopathy type 1X (CMD1X). Alternatively spliced transcript variants have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
2218
Clone Number:
ARC2559
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using Fukutin Rabbit mAb (CAB1385) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
