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FUBP1 Rabbit Monoclonal Antibody (CAB9077)

SKU:
CAB9077
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
FBP
FUBP
hDH V
Research Area:
Epigenetics and Nuclear Signaling
$167 - $503
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:FUBP1 Rabbit Monoclonal Antibody
SKU:CAB9077
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 545-644 of human FUBP1 (Q96AE4).
Sequence:YQQQ AQPP PAAP AGAP TTTQ TNGQ GDQQ NPAP AGQV DYTK AWEE YYKK MGQA VPAP TGAP PGGQ PDYS AAWA EYYR QQAA YYAQ TSPQ GMPQ HPPA PQGQ
Tested Applications:WB IHC-P IF/ICC ELISA
Recommended Dilution:WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:100 - 1:500
Synonyms:FBP; FUBP; hDH V; FUBP1
Positive Sample:Mouse brain,Rat brain
Conjugate:Unconjugated
Cellular Localization:Cytoplasm, Nucleoplasm, Nnucleus
Calculated MW:68kDa
Observed MW:75kDa

The protein encoded by this gene is a single stranded DNA-binding protein that binds to multiple DNA elements, including the far upstream element (FUSE) located upstream of c-myc. Binding to FUSE occurs on the non-coding strand, and is important to the regulation of c-myc in undifferentiated cells. This protein contains three domains, an amphipathic helix N-terminal domain, a DNA-binding central domain, and a C-terminal transactivation domain that contains three tyrosine-rich motifs. The N-terminal domain is thought to repress the activity of the C-terminal domain. This protein is also thought to bind RNA, and contains 3'-5' helicase activity with in vitro activity on both DNA-DNA and RNA-RNA duplexes. Aberrant expression of this gene has been found in malignant tissues, and this gene is important to neural system and lung development. Binding of this protein to viral RNA is thought to play a role in several viral diseases, including hepatitis C and hand, foot and mouth disease. Alternative splicing results in multiple transcript variants.

Purification Method:Affinity purification
Gene ID:8880
Clone Number:ARC1403
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using FUBP1 Rabbit mAb (CAB9077) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.

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