FUBP1 Rabbit Monoclonal Antibody (CAB9077)
- SKU:
- CAB9077
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- FBP
- FUBP
- hDH V
- Research Area:
- Epigenetics and Nuclear Signaling
Description
Product Name: | FUBP1 Rabbit Monoclonal Antibody |
SKU: | CAB9077 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 545-644 of human FUBP1 (Q96AE4). |
Sequence: | YQQQ AQPP PAAP AGAP TTTQ TNGQ GDQQ NPAP AGQV DYTK AWEE YYKK MGQA VPAP TGAP PGGQ PDYS AAWA EYYR QQAA YYAQ TSPQ GMPQ HPPA PQGQ |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:100 - 1:500 |
Synonyms: | FBP; FUBP; hDH V; FUBP1 |
Positive Sample: | Mouse brain,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleoplasm, Nnucleus |
Calculated MW: | 68kDa |
Observed MW: | 75kDa |
The protein encoded by this gene is a single stranded DNA-binding protein that binds to multiple DNA elements, including the far upstream element (FUSE) located upstream of c-myc. Binding to FUSE occurs on the non-coding strand, and is important to the regulation of c-myc in undifferentiated cells. This protein contains three domains, an amphipathic helix N-terminal domain, a DNA-binding central domain, and a C-terminal transactivation domain that contains three tyrosine-rich motifs. The N-terminal domain is thought to repress the activity of the C-terminal domain. This protein is also thought to bind RNA, and contains 3'-5' helicase activity with in vitro activity on both DNA-DNA and RNA-RNA duplexes. Aberrant expression of this gene has been found in malignant tissues, and this gene is important to neural system and lung development. Binding of this protein to viral RNA is thought to play a role in several viral diseases, including hepatitis C and hand, foot and mouth disease. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 8880 |
Clone Number: | ARC1403 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |