The Anti-FUBP1 Antibody (CAB9077) is a vital tool for researchers studying the FUBP1 protein, an essential transcription factor involved in regulating gene expression. This antibody, produced and validated in rabbits, exhibits high specificity and sensitivity when analyzing human samples, especially in Western blot applications.FUBP1, also known as far upstream element-binding protein 1, is crucial in controlling the expression of genes involved in cell growth, development, and differentiation. Dysregulation of FUBP1 has been linked to various diseases, including cancer and neurological disorders.
By targeting FUBP1 with this antibody, researchers can gain insights into its role in disease progression and potentially identify novel therapeutic targets.With its ability to efficiently detect FUBP1 in a variety of cell types, this antibody is a valuable tool for studies in molecular biology, cancer research, and neurobiology. By using the Anti-FUBP1 Antibody, researchers can deepen their understanding of FUBP1 function and its implications in disease pathology, paving the way for new treatment strategies and diagnostic tools.
Product Name:
FUBP1 Rabbit Monoclonal Antibody
SKU:
CAB9077
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 545-644 of human FUBP1 (Q96AE4).
The protein encoded by this gene is a single stranded DNA-binding protein that binds to multiple DNA elements, including the far upstream element (FUSE) located upstream of c-myc. Binding to FUSE occurs on the non-coding strand, and is important to the regulation of c-myc in undifferentiated cells. This protein contains three domains, an amphipathic helix N-terminal domain, a DNA-binding central domain, and a C-terminal transactivation domain that contains three tyrosine-rich motifs. The N-terminal domain is thought to repress the activity of the C-terminal domain. This protein is also thought to bind RNA, and contains 3'-5' helicase activity with in vitro activity on both DNA-DNA and RNA-RNA duplexes. Aberrant expression of this gene has been found in malignant tissues, and this gene is important to neural system and lung development. Binding of this protein to viral RNA is thought to play a role in several viral diseases, including hepatitis C and hand, foot and mouth disease. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
8880
Clone Number:
ARC1403
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using FUBP1 Rabbit mAb (CAB9077) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
