The Anti-FOLR1 Chimeric Recombinant Rabbit Monoclonal Antibody (HDAB0259) is a highly specific antibody designed for research involving FOLR1, a cell surface receptor involved in folate metabolism and transport. This antibody, raised in rabbits, is validated for use in various applications such as immunohistochemistry, immunofluorescence, and flow cytometry.FOLR1, also known as folate receptor alpha, plays a crucial role in the uptake of folate into cells, making it a target of interest in cancer research and therapy. The Anti-FOLR1 antibody binds specifically to the FOLR1 protein, enabling precise detection and analysis in cells and tissues.
Its high reactivity with human samples makes it ideal for studying the expression and function of FOLR1 in cancer biology and therapeutics.Understanding the role of FOLR1 in folate metabolism and cancer progression is essential for developing targeted therapies that exploit the receptor's function. The Anti-FOLR1 antibody provides researchers with a valuable tool for investigating the involvement of FOLR1 in tumorigenesis and exploring its potential as a biomarker or therapeutic target in cancer treatment.
SKU:
HDAB0259
Size:
100 µg
Clonality:
Monoclonal
Clone:
DMC391
Synonyms:
FBP, FOLR, FRalpha
Applications:
Flow Cyt
Recommended Dilution:
Flow Cyt 1:100
Host Species:
Rabbit
Isotype:
Rabbit/Human Fc chimeric IgG1
Reactivity:
Human
Purification Method:
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene.
