Folate Binding Protein (FBP)/FOLR1 Monoclonal Antibody (CAB20726)
The Anti-Folate Binding Protein (FBP/FOLR1) Antibody (CAB20726) is a vital tool for research involving Folate Binding Protein/Folate Receptor 1 (FBP/FOLR1), a key protein involved in the cellular uptake of folate. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By targeting the FBP/FOLR1 protein, this antibody enables researchers to accurately detect and analyze the expression of this important protein in a variety of cell types, making it ideal for studies in cancer research and immunology.
FBP/FOLR1 plays a crucial role in regulating the uptake and utilization of folate, which is essential for numerous cellular processes including DNA synthesis and repair. Dysregulation of FBP/FOLR1 has been linked to various diseases, including cancer and neurological disorders, making it a promising target for therapeutic interventions. By using the Anti-Folate Binding Protein (FBP/FOLR1) Antibody, researchers can gain valuable insights into the role of this protein in health and disease, ultimately leading to the development of novel treatment strategies.
Product Name:
Folate Binding Protein (FBP)/FOLR1 Monoclonal Antibody
SKU:
CAB20726
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Folate Binding Protein(FBP) / FOLR1 (NP_000793.1).
The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
2348
Clone Number:
ARC50859
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of HeLa cells, using Folate Binding Protein(FBP) / FOLR1 antibody (CAB20726) at1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
