The Anti-Flap Antibody (CAB19632) is a valuable tool for researchers studying flap endonuclease 1 (FEN1), a key enzyme involved in DNA replication and repair processes. This polyclonal antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By targeting the FEN1 protein, this antibody allows for the detection and analysis of FEN1 expression in a variety of cell types, making it an ideal choice for research in molecular biology and genetic diseases.
FEN1 is essential for maintaining genomic stability and preventing mutations by properly processing DNA structures during replication and repair. Mutations in FEN1 have been associated with various diseases, including cancer, premature aging syndromes, and neurodegenerative disorders. By investigating the function and regulation of FEN1 using this antibody, researchers can gain valuable insights into the underlying mechanisms of these conditions and potentially identify new therapeutic targets.
Product Name:
FLAP Rabbit Monoclonal Antibody
SKU:
CAB19632
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 62-161 of human FLAP (P20292).
This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
Purification Method:
Affinity purification
Gene ID:
241
Clone Number:
ARC2204
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using FLAP Rabbit mAb (CAB19632) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
