Fibrillarin/U3 RNP Rabbit Monoclonal Antibody (CAB0850)
- SKU:
- CAB0850
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
Product Name: | Fibrillarin/U3 RNP Rabbit Monoclonal Antibody |
SKU: | CAB0850 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 222-321 of human Fibrillarin/U3 RNP (P22087). |
Sequence: | KYRM LIAM VDVI FADV AQPD QTRI VALN AHTF LRNG GHFV ISIK ANCI DSTA SAEA VFAS EVKK MQQE NMKP QEQL TLEP YERD HAVV VGVY RPPP KVKN |
Tested Applications: | WB IF/ICC IP ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells |
Synonyms: | FIB; FLRN; Nop1; RNU3IP1; Fibrillarin/U3 RNP |
Positive Sample: | 293T,Hep G2,Jurkat,Mouse spleen,Rat liver |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus, nucleolus. |
Calculated MW: | 34kDa |
Observed MW: | 37kDa |
This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8% of humans with the autoimmune disease scleroderma recognize fibrillarin.
Purification Method: | Affinity purification |
Gene ID: | 2091 |
Clone Number: | ARC0506 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |