The FGFR4 Chimeric Recombinant Rabbit Monoclonal Antibody (HDAB0286) is a cutting-edge tool for research involving FGFR4, a cell surface receptor known for its role in cell growth, differentiation, and survival. This antibody, developed using advanced recombinant technology, offers high specificity and sensitivity in detecting FGFR4 protein in human samples. Validated for use in immunofluorescence and immunohistochemistry applications, it enables precise localization and visualization of FGFR4 in various cell types and tissues.
FGFR4, a member of the fibroblast growth factor receptor family, is implicated in cancer development and progression, making it a promising target for anti-cancer therapies. By targeting FGFR4, researchers aim to disrupt aberrant signaling pathways that promote tumor growth and metastasis. The FGFR4 Chimeric Recombinant Rabbit Monoclonal Antibody (HDAB0286) provides a powerful tool for investigating the role of FGFR4 in cancer biology, facilitating the development of targeted therapies with potential clinical applications.
SKU:
HDAB0286
Size:
100 µg
Clonality:
Monoclonal
Clone:
DMC460
Synonyms:
CD334， JTK2， TKF
Applications:
Flow Cyt
Recommended Dilution:
Flow Cyt 1:100
Host Species:
Rabbit
Isotype:
Rabbit/Human Fc chimeric IgG1
Reactivity:
Human
Purification Method:
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
The protein encoded by this gene is a tyrosine kinase and cell surface receptor for fibroblast growth factors. The encoded protein is involved in the regulation of several pathways, including cell proliferation, cell differentiation, cell migration, lipid metabolism, bile acid biosynthesis, vitamin D metabolism, glucose uptake, and phosphate homeostasis. This protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment, and a cytoplasmic tyrosine kinase domain. The extracellular portion interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. [provided by RefSeq, Aug 2017]
