The Anti-FCGR3A Chimeric Recombinant Rabbit Monoclonal Antibody (HDAB0209) is a high-quality antibody designed for research involving FCGR3A, a cell surface receptor implicated in immune responses and inflammation. This chimeric antibody, produced in rabbits, is highly specific and reactive with human samples, making it a reliable tool for various immunological studies.FCGR3A, also known as CD16A, plays a crucial role in mediating antibody-dependent cellular cytotoxicity (ADCC) and immune responses to pathogens. Its expression on immune cells like natural killer (NK) cells and macrophages makes it a valuable target for understanding immune cell interactions and therapeutic interventions in conditions like cancer and autoimmune diseases.
The Anti-FCGR3A Chimeric Recombinant Rabbit Monoclonal Antibody (HDAB0209) is validated for use in Western blot applications, enabling precise detection and analysis of FCGR3A in different cell types. Its high specificity and sensitivity make it an ideal tool for researchers in immunology, oncology, and inflammatory disease studies seeking to unravel the complex mechanisms involving FCGR3A in immune regulation.
SKU:
HDAB0209
Size:
100 µg
Clonality:
Monoclonal
Clone:
DMC219
Synonyms:
FCGR3A,CD16A,FCG3,FCGR3,IGFR3
Applications:
ELISA, Flow Cyt
Recommended Dilution:
ELISA 1:5000-10000; Flow Cyt 1:100
Host Species:
Rabbit
Isotype:
Rabbit/Human Fc chimeric IgG1
Reactivity:
Human
Purification Method:
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
