The Anti-FADD Antibody (CAB20252) is a powerful tool for researchers studying programmed cell death and the regulation of apoptosis. FADD (Fas-associated death domain protein) is a key adapter molecule involved in the death receptor-mediated apoptosis pathway, and this polyclonal antibody, raised in rabbits, specifically targets FADD protein in human samples.Validated for use in Western blot applications, the Anti-FADD Antibody offers high reactivity and specificity, enabling accurate detection and analysis of FADD in various cell types. This antibody is a valuable asset for studies in cell biology, cancer research, and the development of therapeutic strategies targeting the apoptosis pathway.
Understanding the role of FADD in apoptosis is essential for unraveling the molecular mechanisms of cell death and survival, paving the way for innovative treatments for cancer and other diseases where dysregulation of apoptosis plays a significant role. Researchers can rely on the Anti-FADD Antibody to advance their studies and contribute to the ongoing progress in the field of cell death research.
Product Name:
FADD Rabbit Polyclonal Antibody
SKU:
CAB20252
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-205 of mouse FADD (NP_034305.1).
Predicted to enable several functions, including caspase binding activity; death effector domain binding activity; and tumor necrosis factor receptor superfamily binding activity. Involved in several processes, including hematopoietic or lymphoid organ development; negative regulation of activation-induced cell death of T cells; and positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation. Acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand; motor neuron apoptotic process; and regulation of programmed cell death. Predicted to be located in several cellular components, including cell body; cytosol; and membrane raft. Predicted to be part of CD95 death-inducing signaling complex and ripoptosome. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Human ortholog(s) of this gene implicated in leukemia. Orthologous to human FADD (Fas associated via death domain).
Purification Method:
Affinity purification
Gene ID:
14082
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse heart, using FADD Rabbit pAb (CAB20252) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
